Erratum: Technology: Less could be more for genome editing

Building bone mass through exercise: could less be more?

A vast literature supports the sensitivity of bone to mechanical loading. When mechanical loading is acutely diminished, as occurs with paralysis or other forms of disuse, bone mass is rapidly degraded. Alternatively, bone is also capable of substantial augmentation following long term exercise. In combination, these observations suggest that mechanical loading of the skeleton is essential for ...

Adding NSAIDs to triptans: could less be more?

Used as monotherapy, triptans and nonsteroidal antiinflammatory drugs (NSAIDs) work well to treat individual attacks of migraine. Both are first-line treatment choices for patients who have episodic headaches and no contraindications to their use. They are not effective for all patients, however, and for others they provide only unreliable or incomplete relief. A substantial body of evidence su...

Could Skype be More Satisfying?

The phenomenal growth of Skype in recent years has surpassed all expectations. Much of the application’s success is attributed to its FEC mechanism, which adds redundancy to the voice streams to sustain audio quality under network impairments. Adopting the quality-of-experience (QoE) approach, i.e., measuring the Mean Opinion Scores (MOS), we examine how much redundancy Skype adds to its voice ...

Reframing treatment for ductal carcinoma in situ: could less be more?

In a typical breast surgery practice, nearly one-fifth of new patients present with ductal carcinoma in situ (DCIS), usually detected on mammography as an incidental finding. Most of these women are otherwise healthy, take care of themselves, have had a mammogram as part of their routine health maintenance, and are now grappling with a “cancer” diagnosis. When explaining to patients that DCIS g...

Genome Editing using NucleofectorTM Technology